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L-Ornithine Benefits, Uses, Side Effects and Functions

Discover the Function, Sources and Benefits of the Health Supplement Ingredient L-Ornithine, or (S)-2,5-Diaminopentanoic Acid

Ornithine – also known as L-ornithine, (S)-2,5-diaminopentanoic acid or (S)-alpha,delta-diaminovaleric acid – is a crystalline amino acid. Different sources refer to it as a nonessential or conditionally essential amino acid, which means that it is normally produced by the body in sufficient amounts; however, dietary supplementation may be beneficial in times of illness, injury or stress. L-ornithine is found in some food sources as well as in health and bodybuilding supplements such as HGH 30,000 Nanograms pills and HGF MAX.

Functions of L-Ornithine

Together with arginine and citrulline, ornithine is one of three amino acids that play a key role in the urea cycle. The conversion of arginine into ornithine and ornithine into citrulline increases urea production while lowering ammonia concentrations in the blood. Citrulline subsequently binds with aspartate to form arginosuccinate, which breaks down into free arginine and fumarate; through this process, ornithine is metabolized back into arginine by the liver. Because L-ornithine helps accelerate the excretion of ammonia, it is believed to promote proper liver function, prevent fatigue and enhance performance during prolonged exercise. Evidence also suggests that L-ornithine may stimulate human growth hormone (HGH) production, thereby serving as a natural HGH releaser.

Sources of L-Ornithine

The human body manufactures ornithine from the amino acid arginine as part of the urea cycle. Dietary sources of L-ornithine include protein-rich foods such as beef, chicken, pork, fish, eggs, dairy products, peanuts and soybeans. L-ornithine may also be consumed in natural dietary supplements.

L-Ornithine Benefits and Uses

Among the benefits of ornithine is its ability to detoxify ammonia levels in the bloodstream; because of this function, it can be used to treat hepatic encephalopathy (a brain complication caused by liver disease). It also appears to help reduce fatigue and mitigate the effects of alcohol consumption, improving sleep quality and decreasing negative feelings the next morning. In addition, L-ornithine may promote wound healing, contribute to immune system function, support weight management, reduce stress and improve overall mood. Some evidence suggests L-ornithine acts as a natural HGH releaser, or HGH secretagogue. Because of its ability to boost HGH production and reduce fatigue, L-ornithine supplements are often taken to improve athletic performance, enhance muscle growth and increase endurance.

Side Effects of L-Ornithine and Potential Interactions

L-ornithine supplements are generally considered safe for adults; no serious side effects or drug interactions have been reported at doses of 2 to 6 grams per day. However, excessive doses (more than 10 grams per day) may potentially cause intestinal distress or diarrhea in some users.

More detailed safety information on L-ornithine dosing, side effects and interactions can be found on Examine.com. As with any medication or health supplement, it is best to consult your physician before taking dietary supplements containing L-ornithine.

L-Ornithine Research and Studies

Various research studies have shown that L-ornithine can be used therapeutically for certain medical conditions as well as to enhance overall health, well being and athletic performance. For example, a group of Polish researchers reported that L-ornithine-L-aspartate (LOLA) supplementation has the ability to lower blood ammonia concentration, eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis and stimulate tissue regeneration, while a Japanese study determined that healthy office workers who consumed a combination of caffeine and ornithine had higher mood ratings, less fatigue and better concentration than those who consumed caffeine alone. Japanese researchers also tested the effects of L-ornithine on salivary cortisol, mood and feelings of fatigue the morning after alcohol consumption, and found that L-ornithine supplements lowered cortisol levels, increased sleep length and significantly decreased feelings of fatigue, anger/hostility and confusion.

Study findings published in the Nutrition Journal and Nutrition Research revealed that L-ornithine not only has the potential to relieve stress and improve sleep quality in fatigued office workers, but also to reduce physical fatigue during exercise. Researchers stated that the decrease in physical fatigue is due to L-ornithine’s ability to modulate lipid and amino acid metabolism, thereby increasing the efficiency of energy consumption. Furthermore, a recent animal study published in the Brain Research Bulletin found that L-ornithine reduced body weight, abdominal fat and food intake in rats.

Beyond the research indicating L-ornithine’s potential to reduce fatigue and overall body weight, several studies suggest that it can improve strength and HGH levels. A study published in the Journal of Sports Medicine and Physical Fitness revealed that arginine and ornithine supplementation paired with a high-intensity strength-training program increased total strength and lean body mass in a relatively short period of time. The article also reported that the arginine and ornithine supplements aided in recovery from chronic stress by quelling tissue breakdown, as evidenced by lower urinary hydroxyproline levels. Furthermore, a double-blind study published in the Journal of Strength and Conditioning Research found that ornithine and arginine supplementation increased human growth hormone (HGH) and insulin-like growth factor-1 (IGF-1) serum levels after heavy-resistance exercise in strength-trained athletes. While further research is needed, the preliminary findings on L-ornithine supplements show significant promise for improving athletic performance, building muscle and elevating HGH levels.

For additional L-ornithine research, refer to the PubMed site sponsored by the National Institutes of Health (NIH).

HGH.com Supplements With L-Ornithine

Athletes, bodybuilders and fitness enthusiasts seeking to leverage the benefits of L-ornithine can find this amino acid among the ingredients in natural health and bodybuilding supplements from HGH.com:

HGH Pills – Purity Select’s HGH 30,000 Nanograms pills are formulated to boost growth hormone production with a powerful combination of L-group amino acids, including L-ornithine. As one of HGH.com’s best-selling products, these capsules help promote muscle growth, increased energy, fat-burning and other health benefits.

HGF MAX – Scientifically designed to increase HGH production, these Purity Select capsules contain a proprietary blend of ingredients including L-ornithine and other key amino acids. Taking HGF MAX as a dietary supplement can help build muscle, enhance muscle tone, improve stamina and increase metabolism.

References (Function, Sources, Benefits/Uses and Side Effects/Interactions):

Busch, Sandi. “Benefits of L-Arginine and L-Ornithine”; published in the “Nutrition Facts” section on Livestrong.com; July 13, 2014. <http://www.livestrong.com/article/502331-the-benefits-of-l-arginine-ornithine>

Examine.com. “Ornithine”; published under “Supplements”; accessed April 13, 2015. <http://examine.com/supplements/Ornithine>

Marie, Joanne. “What Does the Amino Acid L-Ornithine Do?”; published in the “Alternative Remedies” section on Livestrong.com; May 14, 2014. <http://www.livestrong.com/article/22017-amino-acid-l-ornithine>

National Center for Biotechnology Information, U.S. National Library of Medicine. “L-ornithine”; Compound Summary for CID 6262 in PubChem Open Chemistry Database; accessed April 13, 2015. <http://pubchem.ncbi.nlm.nih.gov/compound/L-ornithine>

Somera, Anna Lisa. “Foods With Ornithine”; published in the “Vitamins and Supplements” section on Livestrong.com; August 16, 2013. <http://www.livestrong.com/article/165604-foods-with-ornithine>

University of Maryland Shore Regional Health. “Amino Acids”; published in the “Medical Reference Guide” section; last updated April 23, 2014. <http://umm.edu/system-hospital-sites/shore-health/health/medical/ency/articles/amino-acids>

WebMD and Natural Medicines Comprehensive Database. “Ornithine”; published under “Vitamins & Supplements”; accessed April 13, 2015. <http://www.webmd.com/vitamins-supplements/ingredientmono-200-ornithine.aspx?activeingredientid=200&activeingredientname=ornithine>

Research Sources:

Demura, Shinichi; Takayoshi Yamada; et al. “The Effect of L-Ornithine Hydrochloride Ingestion on Performance During Incremental Exhaustive Ergometer Bicycle Exercise and Ammonia Metabolism During and After Exercise”; European Journal of Clinical Nutrition; October 2010. <http://www.ncbi.nlm.nih.gov/pubmed/20717126>

Elam, R.P.; D.H. Hardin; et al. “Effects of Arginine and Ornithine on Strength, Lean Body Mass and Urinary Hydroxyproline in Adult Males”; Journal of Sports Medicine and Physical Fitness; March 1989. <http://www.ncbi.nlm.nih.gov/pubmed/2770269>

Kokubo, Takeshi; Emiko Ikeshima; et al. “A Randomized, Double-Masked, Placebo-Controlled Crossover Trial on the Effects of L-Ornithine on Salivary Cortisol and Feelings of Fatigue of Flushers the Morning After Alcohol Consumption”; Biopsychosocial Medicine; February 18, 2013. <http://www.ncbi.nlm.nih.gov/pubmed/23414576>

Konishia, Yuuki; Yasutaka Koosaka; et al. “L-Ornithine Intake Affects Sympathetic Nerve Outflows and Reduces Body Weight and Food Intake in Rats”; Brain Research Bulletin; February 2015. <http://www.ncbi.nlm.nih.gov/pubmed/25526897>

Misaizu, Akane; Takeshi Kokubo; et al. “The Combined Effect of Caffeine and Ornithine on the Mood of Healthy Office Workers”; Preventative Nutrition and Food Science; December 2014. <http://www.ncbi.nlm.nih.gov/pubmed/25580405>

Miyake, Mika; Takayoshi Kirisako; et al. “Randomised Controlled Trial of the Effects of L-Ornithine on Stress Markers and Sleep Quality in Healthy Workers”; Nutrition Journal; June 3, 2014. <http://www.ncbi.nlm.nih.gov/pubmed/24889392>

Sikorska, Hanna; Janusz Cianciara; and Alicja Wiercińska-Drapało. “Physiological Functions of L-Ornithine and L-Aspartate in the Body and the Efficacy of Administration of L-Ornithine-L-Aspartate in Conditions of Relative Deficiency” (article published in Polish); Polski Merkuriusz Lekarski; June 2010. <http://www.ncbi.nlm.nih.gov/pubmed/20642112>

Sugino, Tomohiro; Tomoko Shirai; et al. “L-Ornithine Supplementation Attenuates Physical Fatigue in Healthy Volunteers by Modulating Lipid and Amino Acid Metabolism”; Nutrition Research; November 2008. <http://www.ncbi.nlm.nih.gov/pubmed/19083482>

Zajac, Adam; Stanisław Poprzęcki; et al. “Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes”; Journal of Strength and Conditioning Research; April 2010. <http://www.ncbi.nlm.nih.gov/pubmed/20300016>




Online Supplement Store HGH.com Celebrates Brand Milestones Over 12-Year History

Bodybuilding and Natural Human Growth Hormone Supplement Company HGH.com Celebrates Brand Milestones Over 12-Year History

HGH.com was recently featured in Yahoo Finance, The Street, Region 8 ABC News, Health Technology.net, Pharmacy Choice, and many more top media outlets

"HGH.com has grown and evolved significantly over the past 12 years; but one thing that hasn't changed is our long-standing history of excellence," asserted Dan Smith of HGH.com. "We have earned a reputation for the highest-quality, most effective HGH supplements on the market, and our customers include everyone from amateur and professional bodybuilders to fitness enthusiasts and health buffs. And while we're committed to delivering the industry's best products, we're equally focused on providing an exceptional customer experience."

Smith notes that HGH.com is much more than an online vitamin and supplement store; he has continually added information, tools and resources through the years to create an extensive knowledge base for anyone looking to learn more about human growth hormones or obtain advice on nutrition and fitness. Consumers and the public at large can visit the HGH.com blog for detailed information on natural HGH supplement ingredients and uses, and for fitness and bodybuilding tips from IFBB pros and other experts. Additional resources are available on the HGH.com Facebook page, Twitter profile and YouTube channel.

"I'd like to thank our loyal customers for their ongoing support of HGH.com; our 12 years in business are a testament to their belief in us and the effectiveness of our products," said Smith. "We pledge to continue offering the industry's best natural HGH supplements, and we intend to upgrade our formulations and expand our product lines based on nutraceutical research as well as input from our IFBB pros and customers. I encourage consumers and the public to reach out to us with their questions, feedback and suggestions—we welcome it all!"

HGH.com Highlights Brand Evolution and Expansion, From Anti-Aging Solutions to a Full Range of Natural Health and Bodybuilding Supplements Created With Input From IFBB Pros - Read the full story on Yahoo Finance - http://finance.yahoo.com/news/bodybuilding-natural-human-growth-hormone-124000821.html.




How to Increase HGH Levels Naturally

Top 7 Ways to Naturally Boost Your Body’s Human Growth Hormone (HGH) Levels

By Dan Smith of HGH.com

In recent years, I’ve seen a growing level of interest in how to increase HGH levels naturally, particularly among bodybuilders and athletes. Given the controversy and issues associated with synthetic HGH injections, many people are seeking out natural ways to increase their body’s own production of HGH. This is something that I do myself, and it’s a topic I’ve often discussed with our HGH.com-sponsored athletes – IFBB pros Tricky Jackson, Ben White and Tara Silzer. So I decided to compile our top tips in one blog post, which highlights seven effective ways to naturally boost HGH levels.

HGH Basics and Functions

Before I get into our recommendations, let’s start with a quick review of the basics. Human growth hormone, also known as HGH, is a type of polypeptide hormone secreted by the pituitary gland. As the name implies, HGH triggers growth and repair of bone, cartilage, tissue and muscle. It also helps to improve body composition by increasing muscle mass and metabolizing fat. The pituitary gland produces its highest quantities of HGH during childhood and puberty to support the body’s growth and development. Once a child has reached full adult height, HGH production decreases substantially. In adulthood, HGH tends to be secreted in smaller bursts at specific times – during sleep, after exercise and in response to bodily stress or trauma.

Top 7 Ways to Naturally Increase HGH Levels

While the body generally follows its own set patterns for HGH secretion after puberty, there are a number of proven methods for boosting production on an ongoing basis:

1. Seek alternatives to synthetic HGH injections. While injectable growth hormones have been shown to increase HGH levels, there are a number of issues associated with this practice – including the high cost of injections as well as the fact that they are illegal without a prescription. Another lesser-known caveat is that pumping the body with high levels of artificial growth hormones may actually cause the body to decrease production of its own natural HGH. So, in the long run, it’s better to find natural ways to stimulate increased HGH secretion.

2. Get enough sleep. Since the majority of HGH production in adults occurs overnight during slow-wave sleep (or “deep” sleep), it is essential to get sufficient high-quality sleep – ideally, 7 to 8 hours per night. To help elevate HGH levels, try to adhere to a regular sleep routine: go to bed at the same time every evening and wake up at the same time each morning. It’s also important to have uninterrupted sleep, so avoid consuming alcohol or caffeine before bedtime, as they can interfere with normal sleep patterns. Try to minimize light and noise to avoid interruptions to your sleep schedule, and keep your bedroom at a comfortable temperature so that you don’t awake in the middle of the night shivering or sweating.

3. Adhere to a healthy diet. There is an inverse relationship between insulin and HGH – higher levels of insulin suppress HGH production. Therefore, it is critical to consume the right foods at the right time to regulate insulin levels and promote HGH release. Many experts recommend eating multiple small meals over the course of the day, and the majority agree that it is best to limit your intake of highly processed, complex carbohydrates (like white bread and white rice) as well as sugary food and beverages (including soda and sports drinks made with high-fructose corn syrup), as these can trigger a spike in insulin.

Your best bet is to build your diet around high-fiber, protein-rich foods, such as vegetables, fruits, nuts and beans/legumes. Opt for low-glycemic, slow-digesting carbohydrates like oatmeal, pears, apples, sweet potatoes and brown rice. To help minimize insulin secretion, try eating a low-carb, high-protein snack a few hours before bedtime – think nuts like almonds, pistachios and walnuts; pumpkin or sunflower seeds; edamame; hummus; yogurt; or cottage cheese.

4. Engage in high-intensity interval training. While proper sleep and nutrition are both effective ways to support a natural increase in HGH levels, exercise also plays a critical role. Many different types of exercise can help maintain a healthy body and regulate insulin levels, but high-intensity interval training in particular has the potential to naturally boost HGH levels. This occurs in direct response to the stress on your muscles, signaling the pituitary gland to secrete more HGH to repair the tissue. Several studies have examined the effects of this exercise-induced growth hormone response (EIGR) and determined the associated benefits.

5. Consume whey protein before and after exercise. Research has shown that consuming a rapidly absorbed protein, such as whey protein, may help promote optimal muscle building after resistance exercise. Another study found that consuming whey protein half an hour before resistance training can accelerate metabolism not only during exercise, but up to 24 hours after a workout. HGH.com offers several high-quality whey protein mixes designed to enhance muscularity and stimulate HGH production, including CytoSport Vanilla Whey Protein, Elite Chocolate Mint Whey Protein, Elite Butter Toffee Whey Protein, IsoBolic Vanilla Whey Protein and Multi-Pro Chocolate Whey Protein.

6. Practice occasional fasting. A healthy diet is vital to provide the energy you need to complete intense workouts. However, some studies have suggested that intermittent fasting may be an effective way to balance blood-sugar levels and trigger HGH release. If your workout schedule allows for it, you might want to try periodic fasting on any off days in your training.

7. Add natural HGH releasers to your dietary supplements. Unlike injectable HGH, which introduces synthetic chemicals into your system, natural HGH releasers stimulate your body to produce more of its own HGH. Look for HGH supplements that contain proven natural ingredients, such as L-arginine, L-glutamine, L-leucine, L-tyrosine, bovine colostrum and others. You’ll find many of these naturally derived ingredients in Purity Select health and bodybuilding supplements from HGH.com, including HGH 30,000 Pills, HGH 30,000 Spray, Somatropinne HGH, DBol-GH, Ana-GH and HGH Testosterone Plus.

Following these recommendations will help you increase HGH levels naturally and in a healthy way while also enabling you to attain peak physical condition. Are there any other tips and best practices you implement to boost your HGH production? We invite you to join the conversation and post your comments below!

References:

Besedovsky, Luciana; Lange, Tanja; and Born, Jan. “Sleep and Immune Function”; Pflugers Archiv: European Journal of Physiology; January 2012. <http://www.ncbi.nlm.nih.gov/pubmed/22071480>

Churchward-Venne, Tyler A.; Burd, Nicholas A; and Phillips, Stuart M. “Nutritional Regulation of Muscle Protein Synthesis With Resistance Exercise: Strategies to Enhance Anabolism”; Nutrition & Metabolism; May 2012. <http://www.ncbi.nlm.nih.gov/pubmed/22594765>

Godfrey, Richard J.; Madgwick, Zahra; and Whyte, Gregory P. “The Exercise-Induced Growth Hormone Response in Athletes”; Sports Medicine; July 2003. <http://www.ncbi.nlm.nih.gov/pubmed/12797841>

Hackney, Kyle J.; Bruenger, Adam J.; Lemmer, Jeffrey T. “Timing Protein Intake Increases Energy Expenditure 24 H After Resistance Training”; Medicine & Science in Sports & Exercise; May 2010. <http://www.ncbi.nlm.nih.gov/pubmed/19997003>

Harvard Medical School. “Growth Hormone, Athletic Performance, and Aging”; Harvard Men’s Health Watch; May 2010; accessed November 9, 2014. <http://www.health.harvard.edu/newsletters/Harvard_Mens_Health_Watch/2010/May/growth-hormone-athletic-performance-and-aging>

Ho, Kian Y.; Veldhuis, Johannes D.; et al. “Fasting Enhances Growth Hormone Secretion and Amplifies the Complex Rhythms of Growth Hormone Secretion in Man”; The Journal of Clinical Investigation; April 1988. <http://www.ncbi.nlm.nih.gov/pubmed/3127426>

Jackson, Joe. “Unlock Your Potential: How to Boost Your HGH Levels”; Men’s Fitness; accessed November 9, 2014. <http://www.mensfitness.com/nutrition/supplements/unlock-your-potential-how-to-boost-your-hgh-levels>

Nindl, Bradley C.; Pierce, Joseph R.; et al. “Twenty-Hour Growth Hormone Secretory Profiles after Aerobic and Resistance Exercise”; Medicine & Science in Sports & Exercise; October 2014. <http://www.ncbi.nlm.nih.gov/pubmed/24576855>





Anapolan Max - How The Ingredients in A-Max 50 Will Help You Build Muscle | An HGH.com Product Review

How The Ingredients of Anapolan Max (A-Max 50) by HGH.com Will Help You Gain Muscle

Anapolan Max - New Look, Same Great Formula!

 
 
Our #1 goal is delivering products that are safe, natural, and that work as advertised. Our product Anapolan Max, renamed for short "A-Max 50", has been a staple for muscle builders around the world for years. It's ingredients will help you rapidly grow muscle and for this reason, it's great for all types of bodybuilders.
 
Note - for other muscle builders and bodybuilding supplements, visit http://www.hgh.com.
 
Let's review the proprietary blend of ingredients for A-Max 50.
 
  • L-Tyrosine: This is a non-essential amino acid that that is an important building block for protein. It's reaction in your body helps create the neurotransmitter dopamine in your body, in addition to other hormones.  This amino acid is made in your body from phenylalanine. Because this ingredient helps in the production of dopamine, it also can have positive effects on focus and other mental and physical stimulations.
  • Shilajit: Known as "Blood of the mountain". Shilajit can boost fertility and increase testosterone levels. Ayurvedic healers even consider it to be an anti-aging substance, which can help balance HGH levels in your body. One of the main components of Shilajit is fulvic acid, which can clean the body of heavy metals, in turn causing testosterone levels and sperm count to rise. Researchers believe that Shilajit can reduce damage from free radicals in the testes and boost production of testosterone.
  • Tribulus: Proven to be effective for muscle building, the bodybuilding industry has looked to Tribulus for years. It's a flowering plant, originally native to warm climates, but now available throughout the world. In the 90's, Olympic weight lifting teams were quoted as using Tribulus to improve their performance. Tribulus can help improve performance by increasing testosterone levels, but it will also speed up the recovery of the muscles immediately following exercise. This is a great substance for helping protein synthesis for new muscles, helping repair and regrow new muscle tissue.
  • Mucuna Pruiens: Mucuna can be a great addition to any bodybuilders diet. It is rich in the amino acid L-Dopa, which helps lower cholesterol and blood sugar levels. It also increases the production of HGH in your body, which can increase your ability to build lean muscle and burn fat.
  • Epimedium: Also used as an ingredient for "herbal Viagra" supplements, Epimedium has great bone and muscle benefits. The components of Epimedium can help manage Cortisol levels in the blood. Cortisol levels directly affect body structures affecting bone and muscle deterioration. Thus, but managing Cortisol, Epimediums effect on the body will help prevent bone deterioration and will also cause an increase in muscle mass.
  • DHEA: DHEA is a natural hormone produced by your adrenal gland. Supplementing your DHEA can increase lean muscle mass and reduce body fat. DHEA is highest in your youth (mid 20's), and sharply declines over the years starting in your mid 30's. This ingredient is a highly talked about supplement and more studies are needed, but many bodybuilder experts will tell you that DHEA will promote lean muscle gains. Note, most athletic organizations ban DHEA due to its performance enhancing effects.
A-Max is currently available at http://www.hgh.com/anapolan-max.aspx. Buy two, get one free today!






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