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Somatotropin/Somatropin Benefits, Uses, Side Effects and Functions

Discover the Function, Sources and Benefits of Somatotropin Supplements and Somatropin Injections

Somatotropin—also known as human growth hormone (HGH) or simply as growth hormone (GH)—is a polypeptide produced by somatotrope cells in the pituitary gland. It supports skeletal growth in children and adolescents, and plays a role in metabolism, body composition, muscle growth and tissue repair in adults. In addition to the somatotropin naturally produced by the body, a synthetic form of HGH called somatropin is available with a doctor’s prescription. Certain health and bodybuilding supplements may also help increase somatotropin production through natural ingredients known as HGH releasers. Many of these ingredients can be found in the proprietary-blend formulas of Somatropinne HGH, Growth Factor Plus, HGH 30,000 Nanograms, A-MAX 50, and HGF MAX, among others.

Functions of Somatotropin

Children and adolescents require somatotropin for proper growth and development; those with an HGH deficiency may require somatropin injections to achieve normal height. In adults, somatotropin helps maintain healthy tissues and organs. It can also increase bone density, muscle mass, and protein synthesis as well as decrease body fat and improve exercise capacity. Because HGH production naturally declines with age, some adults take somatotropin-boosting supplements to enhance their athletic performance and combat the physical signs of aging.

Sources of Somatotropin/Somatropin

For most individuals, the primary source of somatotropin is the body’s endogenous production by the somatotropic cells of the pituitary gland. The body produces its highest levels of somatotropin during childhood and adolescence; these levels significantly decline when the individual reaches full adult height. Scientists have also developed a synthetic form of somatotropin known as somatropin or somatrem, using E. coli or mammalian cells to create therapeutic proteins in a laboratory setting. Somatropin is chemically identical to the somatotropin that is produced by the pituitary gland and administered by subcutaneous injection. It is a regulated substance, which means it can only be legally prescribed for FDA-approved uses.

Since somatropin injections are not legally available to healthy adults, those seeking the benefits of somatotropin may opt to take natural supplements that are designed to boost the body’s own HGH production. Certain amino acids are recognized as natural HGH releasers—including GABA, arginine, ornithine, glutamine, lysine, tyrosine and glycine—so dietary supplements containing these ingredients may help increase somatotropin levels.

Somatropin Benefits and Uses

The pituitary gland’s secretion of somatotropin supports bodily growth and development throughout childhood and adolescence, so the most common reason for prescribing somatropin is to treat children and teens with HGH deficiency or specific medical conditions. FDA-approved pediatric uses of somatropin include idiopathic growth hormone deficiency, Noonan syndrome, Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, short stature homeobox-containing gene (SHOX) deficiency, and idiopathic short stature.

Although HGH levels naturally decline with age, somatotropin continues to play a role throughout adulthood—helping to regulate metabolism and protein synthesis and promoting organ, tissue and bone health. Somatropin may be legally prescribed to adults who have severe HGH deficiency, which normally occurs due to a pituitary adenoma (tumor) or adenoma-related surgery or radiation treatments. It is also sometimes prescribed to prevent or minimize wasting in AIDS patients.

Somatropin injections can improve bone density, muscle mass and exercise capacity in adults with HGH deficiency, and they can produce similar outcomes in healthy adults. As a result, some bodybuilders and athletes take somatropin to enhance their athletic performance and physique. However, it should be noted that somatropin cannot legally be prescribed for such purposes. Furthermore, the World Anti-Doping Agency (WADA), International Olympic Committee and numerous sports organizations have banned the use of HGH injections among athletes.

Given the potential repercussions associated with illegal somatropin injections, many bodybuilders, athletes and aging adults have starting taking natural HGH supplements to help the body increase its own somatotropin production. Proponents of somatotropin-boosting supplements report that these natural HGH releasers have helped them develop lean muscle, improve their strength and endurance, and recover from intense workouts and injuries more quickly. They also credit HGH supplements with enhancing their body composition and slowing the visible signs of aging.

Somatropin Side Effects

Individuals considering HGH injections should be aware of somatropin side effects and interactions. Some users have experienced an allergic reaction, with symptoms such as itching or rashes, chest pain, difficulty breathing, or swelling of the face, tongue, or throat. Other possible side effects include headaches, nausea, vomiting, blurred vision, fluid retention, swelling of the hands or feet, muscle stiffness or pain, and burning, tingling or numbness in the skin. Somatropin may increase the risk of developing diabetes, cancer or pancreatitis, and it can cause dislocation of the hipbone that results in limping or knee/hip pain. Interactions have been recorded when somatropin is used with estrogen hormone replacement or glucocorticoids (such as prednisone or hydrocortisone), and somatropin can cause adverse effects in patients with diabetes, scoliosis, kidney disease and certain other medical conditions.

Somatotropin-boosting HGH supplements tend to have fewer and less severe side effects than somatropin injections; however, the side effects and interactions will vary depending on the supplement’s ingredients.

More detailed safety information on somatropin side effects, interactions and precautions can be found on the Mayo Clinic website. For natural somatotropin-boosting supplements, refer to the relevant ingredient articles on HGH.com to learn about potential side effects and interactions. As with any medication or health supplement, it is best to consult your physician before using somatropin injections or natural HGH supplements.

Somatotropin/Somatropin Research and Studies

Researchers have conducted numerous studies on both the natural and synthetic forms of somatotropin. Visit the PubMed site sponsored by the National Institutes of Health (NIH) to explore the latest somatotropin research and somatropin studies. For research on specific ingredients that have been shown to boost somatotropin levels, refer to the corresponding ingredient articles on the HGH.com blog.

You will discover there is a wealth of information on at HGH.com. We recently posted this related blog post on HGH/somatotropin: Human Growth Hormone (HGH) Benefits, Uses, Side Effects and Functions.

HGH.com Supplements With Natural Somatotropin/HGH Releasers

Many of the health and bodybuilding supplements available from HGH.com are formulated to naturally increase somatotropin/HGH levels. These products include:

Somatropinne HGH – Purity Select’s natural Somatropinne HGH capsules contain a proprietary blend of L-arginine, cowhage, maca and horny goat weed. As an over-the-counter somatotropin releaser, this supplement is formulated to help athletes gain lean muscle and increased energy while also providing weight-loss and anti-aging benefits.

HGH 30,000 Nanograms Pills and HGH 30,000 Nanograms Spray –Purity Select’s 30,000 Nanogram HGH pills and spray are designed to promote somatotropin production, muscle growth, increased energy and other health benefits. They contain a powerful combination of amino acids—including L-glutamine, L-arginine, L-ornithine, L-lysine, L-glycine, L-valine and L-tyrosine —as well as other natural ingredients such as colostrum, GABA, cowhage (mucuna pruriens), long jack and deer antler velvet.

Growth Factor Plus – As its name suggests, Growth Factor Plus is intended to support height growth as well as bone and joint health. Its proprietary blend of ingredients features amino acids such as L-arginine, L-ornithine, L-lysine, L-glycine, L-glutamine, and L-tyrosine.

HGF MAX – Purity Select HGF MAX is intended to boost somatotropin production, improve muscle tone, build muscle, promote fat loss, boost energy and increase metabolism. Its proprietary blend of ingredients includes arginine, GABA, glutamine, lysine, glycine, tyrosine, ornithine and deer antler velvet.

Ana-GH – These capsules contain a blend of L-group amino acids such as L-leucine and L-valine as well as plant-based ingredients such as horny goat weed and maca. Ana-GH is intended to jumpstart bulking cycles by promoting muscle mass and weight gains, improving protein synthesis, and contributing to joint and muscle repair.

Anapolan-MAX 50 (A-MAX 50) – Anapolan-MAX is formulated to support lean muscle gain while boosting somatotropin production and testosterone levels. Its proprietary blend of ingredients includes L-tyrosine, Tribulus terrestris, cowhage (mucuna pruriens), shilajit and dehydroepiandrosterone.

ClenXDV – Featuring a proprietary blend of DHEA, deer antler velvet, wild yam, Tribulus terrestris and other natural ingredients, ClenXDV is intended to help athletes and bodybuilders build muscle, lose weight and burn fat.

DBol-GH – This anabolic lean muscle gainer is designed to promote lean mass and muscle growth, support muscle recovery and naturally boost HGH levels with a proprietary blend of ingredients that include bovine colostrum, beta-ecdysterone, L-valine and L-leucine.

Dekka – With a blend of Korean ginseng root, yucca bark, wild yam root, and dehydroepiandrosterone, Dekka capsules are formulated to help bodybuilders achieve lean mass, weight gain, muscle building and bulking.

Testosterone Plus – HGH Testosterone Plus features a proprietary blend of long jack, maca, Tribulus terrestris, ginkgo biloba and other natural ingredients that are intended to help build muscle, aid in muscle recovery and boost energy while offering sexual health benefits such as improved libido and stamina.

RoidX Juice – The ingredients in RoidX Juice are designed to help bodybuilders quickly develop muscle and gain weight in addition to supporting muscle recovery. RoidX Juice capsules contain a proprietary blend of Vitamin E, Tribulus terrestris, shilajit and dehydroepiandrosterone.

Winstrol Max – Optimized for cutting cycles, Winstrol Max is formulated to promote lean mass gain and help athletes achieve ripped abs. Its powerful blend of ingredients includes L-group amino acids such as leucine, arginine and valine as well as oat straw (Avena sativa) extract and saw palmetto.

References:

Drug Enforcement Administration. “Human Growth Hormone”; DEA fact sheet; August 2013. <http://www.deadiversion.usdoj.gov/drug_chem_info/hgh.pdf>

U.S. Food and Drug Administration (FDA). “Somatropin Information”; published under “Drug Safety and Availability”; August 4, 2011. <http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm237839.htm>

Kamionka, Mariusz. “Engineering of Therapeutic Proteins Production in Escherichia Coli”; Current Pharmaceutical Biotechnology; February 2011. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179032>

Mayo Clinic. “Somatropin, E-Coli Derived (Subcutaneous Route, Injection Route)”; Mayo Clinic website; last updated April 1, 2015. <http://www.mayoclinic.org/drugs-supplements/somatropin-e-coli-derived-subcutaneous-route-injection-route/description/drg-20071575>

Mayo Clinic. “Somatropin, Mammalian Derived (Injection Route, Subcutaneous Route)”; Mayo Clinic website; last updated April 1, 2015. <http://www.mayoclinic.org/drugs-supplements/somatropin-mammalian-derived-injection-route-subcutaneous-route/description/drg-20071668>

WebMD. “Somatropin Injection”; accessed June 9, 2015. <http://www.webmd.com/drugs/2/drug-6259/somatropin-injection/details>





GABA Benefits, Uses, Side Effects and Functions

Discover the Function, Sources and Benefits of the Health Supplement Ingredient Gamma-Aminobutyric Acid, or GABA

Gamma-aminobutyric acid, more commonly known as GABA, is a non-protein amino acid that functions as a neurotransmitter. GABA and its precursor, glutamate, are the most abundant neurotransmitters in the central nervous system, particularly in the cerebral cortex. Glutamate is an excitatory neurotransmitter while GABA is an inhibitory neurotransmitter, so their actions are complementary. In addition to being produced within the body, GABA is also available as an ingredient in select health and bodybuilding supplements such as HGF MAX and HGH 30,000 Nanograms spray.

Functions of GABA

As an inhibitory neurotransmitter, GABA balances the excitatory effect of glutamate in the developed brain and helps to control cortical stimulation. Due to this action, GABA can have a calming or tranquilizing effect, including anxiolytic and anti-convulsive properties. Evidence suggests it may also stimulate human growth hormone (HGH) production, thereby serving as a natural HGH releaser.

Sources of GABA

GABA is produced by the body, where it is synthesized from glutamate through decarboxylation. While GABA is not naturally found in fresh foods, it can be created through lactobacillus fermentation; therefore, GABA may be consumed in fermented foods such as kimchi, sauerkraut, tempeh, miso, kefir and yogurt, as well as in GABA-fortified foods. In addition, foods that contain GABA’s precursors—glutamic acid or L-glutamine—can help boost GABA levels. Dietary sources of glutamate/glutamine include whole grains, brown rice, beef liver, pork, halibut, mackerel, lentils, broccoli, bananas and tree nuts. Vitamins B-6 and B-12 are required for GABA synthesis, so taking these vitamins may help support GABA production. Finally, GABA may also be consumed orally as an ingredient in natural dietary supplements.

GABA Benefits and Uses

Evidence has shown that GABA may help treat hypertension, so it is sometimes used in medications that are designed to lower blood pressure. The method of action appears to be due to GABA’s ability to suppress the sympathetic nervous activity that leads to high blood pressure. GABA’s anticonvulsant properties suggest that it may be effective in reducing the frequency of seizures in some individuals, while its calming effects may help reduce stress, relieve anxiety, elevate mood, and improve focus and concentration.

A number of studies have indicated that GABA may act as a natural HGH releaser, or HGH secretagogue. In light of its potential to stimulate HGH production, GABA-containing supplements are often taken to support lean muscle growth, decrease body fat and enhance exercise tolerance. Furthermore, GABA is believed to have an analgesic effect, so it may help to alleviate feelings of pain or soreness after an intense workout.

Side Effects of GABA and Potential Interactions

GABA supplementation is generally considered safe for healthy adults; no side effects have been reported at commonly administered dosages. However, since GABA has been shown to reduce blood pressure, supplements containing GABA may increase the risk of hypotension (abnormally low blood pressure) when taken in conjunction with antihypertensive drugs.

More detailed safety information on GABA side effects and interactions can be found in the Natural Medicines Comprehensive Database (subscription required). As with any medication or health supplement, it is best to consult your physician before taking dietary supplements containing GABA.

GABA Research and Studies

Many researchers have explored the use of GABA to treat medical conditions such as hypertension and anxiety. Numerous animal and human studies—including some published in the British Journal of Nutrition, Journal of Physiological Anthropology, Clinical and Experimental Hypertension, Journal of Agricultural and Food Chemistry, and Transgenic Research—have revealed GABA’s ability to lower blood pressure in cases of hypertension. Other studies have demonstrated its relaxing, immunity-enhancing and anti-anxiety effects. According to an article in BioFactors, GABA not only induces relaxation but also reduces anxiety; and evidence suggests it may enhance immunity under stress conditions. An animal study published Neuroscience found that GABA decreases anxiety-like behavior in rats. Furthermore, researchers documented GABA’s neuroprotective effects in the Journal of Microbiology and Biotechnology, which reported that GABA-producing Lactobacillus buchneri protected neuronal cells against neurotoxicant-induced cell death. Some researchers have explored the potential of GABA to be used in an analgesic capacity for pain relief—as described in Advances in Pharmacology, Neurochemical Research and the European Journal of Pharmacology—though further evidence is needed to accurately evaluate its effectiveness for this use.

Multiple studies have indicated that GABA is capable of promoting human growth hormone (HGH) secretion; relevant findings have been published in The Journal of Clinical Endocrinology and Metabolism, Acta Endocrinologica, Medicine and Sport Science, and other journals and textbooks. One study featured in Medicine and Science in Sports and Exercise examined the effect of GABA ingestion on immunoreactive growth hormone (irGH) and immunofunctional growth hormone (ifGH) release at rest and after exercise, and found that GABA elevates both resting and post-exercise HGH concentrations. Bodybuilders and athletes often take GABA supplements to help increase muscle growth, enhance muscle tone, burn fat and improve exercise tolerance. However, while GABA has been shown to stimulate HGH secretion, further clinical studies are needed to prove a direct correlation between GABA and other purported health and fitness benefits.

For additional GABA research, refer to the PubMed site sponsored by the National Institutes of Health (NIH).

HGH.com Supplements With GABA

Athletes, bodybuilders and fitness enthusiasts can leverage the potential benefits of GABA through natural health and bodybuilding supplements from HGH.com:

HGF MAX – Purity Select HGF MAX is intended to boost HGH production with a proprietary blend of ingredients, including GABA and key amino acids. This powerful dietary supplement can help improve muscle tone, build muscle, promote fat loss, boost energy and increase metabolism.

HGH Spray – HGH 30,000 Nanograms is designed to stimulate HGH release through a combination of GABA, L-group amino acids and other natural ingredients. Available in a convenient spray form, this product is formulated to support muscle growth, mass gain, fat burning and other benefits.

References (Function, Sources, Benefits/Uses and Side Effects/Interactions):

Clark, Josh. “Can Food Make People Happy?”; How Stuff Works; accessed May 13, 2015. <http://science.howstuffworks.com/life/food-happiness1.htm>

Examine.com. “GABA”; published under “Supplements”; accessed May 13, 2015. <http://examine.com/supplements/GABA>

Haas, Ryan. “The Effectiveness of GABA as a Weightlifting Supplement”; published in the “Sports and Fitness” section on Livestrong.com; October 24, 2013. <http://www.livestrong.com/article/442474-the-effectiveness-of-gaba-weight-lifting-supplement>

Hunt Renee. “A List of Foods With the Highest GABA”; published in the “Food and Health” section on Livestrong.com; April 19, 2015. <http://www.livestrong.com/article/478780-a-list-of-foods-with-the-highest-gaba>

Natural Medicines Comprehensive Database. “GABA (Gamma-Aminobutyric Acid)”; Natural Medicines Comprehensive Database; updated April 9, 2014. <http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=&s=ND&pt=100&id=464&fs=ND&searchid=51623304>

Petroff, Ognen A.C. “GABA and Glutamate in the Human Brain”; Neuroscientist; December 2002. <http://www.ncbi.nlm.nih.gov/pubmed/12467378>

Stellpflug, Craig. “For a Healthy Brain and Nervous System – Gotta Have GABA”; Natural News; August 13, 2012. <http://www.naturalnews.com/036778_GABA_brain_health_nervous_system.html>

WebMD and Natural Medicines Comprehensive Database. “GABA (Gamma-Aminobutyric Acid)”; published under “Vitamins & Supplements”; accessed May 13, 2015. <http://www.webmd.com/vitamins-supplements/ingredientmono-464-gaba%20%28gamma-aminobutyric%20acid%29.aspx?activeingredientid=464&activeingredientname=gaba%20%28gamma-aminobutyric%20acid%29>

Research Sources:

Abdou, Adham M.; S. Higashiguchi; et al. “Relaxation and Immunity Enhancement Effects of Aamma-Aminobutyric Acid (GABA) Administration in Humans”; BioFactors; 2006. <http://www.ncbi.nlm.nih.gov/pubmed/16971751>

Cavagnini, Francesco; Giampiero Benetti; et al. “Effect of Gamma-Aminobutyric Acid on Growth Hormone and Prolactin Secretion in Man: Influence of Pimozide and Domperidone”; The Journal of Clinical Endocrinology and Metabolism; October 1980. <http://www.ncbi.nlm.nih.gov/pubmed/7419665>

Cavagnini, Francesco; Cecilia Invitti; et al. “Effect of Acute and Repeated Administration of Gamma Aminobutyric Acid (GABA) on Growth Hormone and Prolactin Secretion in Man”; Acta Endocrinologica; February 1980. <http://www.ncbi.nlm.nih.gov/pubmed/7376786>

Cho, Yu Ran; Ji Yoon Chang; and Hae Choon Chang. “Production of β-Aminobutyric Acid (GABA) by Lactobacillus Buchneri Isolated from Kimchi and Its Neuroprotective Effect on Neuronal Cells”; Journal of Microbiology and Biotechnology; January 2007. <http://www.ncbi.nlm.nih.gov/pubmed/18051360>

Enna, S.J. and Kenneth E. McCarson. “The Role of GABA in the Mediation and Perception of Pain”; Advances in Pharmacology; 2006. <http://www.ncbi.nlm.nih.gov/pubmed/17175808>

Hayakawaa, Kazuhito; Masayuki Kimura; et al. “Effect of a Gamma-Aminobutyric Acid-Enriched Dairy Product on the Blood Pressure of Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats”; British Journal of Nutrition; September 2004. <http://www.ncbi.nlm.nih.gov/pubmed/15469644>

Kowaka, Emi; Yasuka Shimajiri; et al. “Field Trial of GABA-Fortified Rice Plants and Oral Administration of Milled Rice in Spontaneously Hypertensive Rats”; Transgenic Research; December 2014. <http://www.ncbi.nlm.nih.gov/pubmed/25542346>

McCarson, Kenneth E. and S.J. Enna. “GABA Pharmacology: The Search for Analgesics”; Neurochemical Research; October 2014. <http://www.ncbi.nlm.nih.gov/pubmed/24532294>

Munro, Gordon; Rikke R. Hansen; and Naheed R. Mirza. “GABA(A) Receptor Modulation: Potential to Deliver Novel Pain Medicines?”; European Journal of Pharmacology; September 15, 2013. <http://www.ncbi.nlm.nih.gov/pubmed/23500203>

Okita, Yoshimitsu; Harunobu Nakamura; et al. “Effects of Vegetable Containing Gamma-Aminobutyric Acid on the Cardiac Autonomic Nervous System in Healthy Young People”; Journal of Physiological Anthropology; 2009. <http://www.ncbi.nlm.nih.gov/pubmed/19483370>

Powers, M. “GABA Supplementation and Growth Hormone Response”; Medicine and Sport Science; 2012. <http://www.ncbi.nlm.nih.gov/pubmed/23075553>

Powers, Michael E.; Joshua F. Yarrow; et al. “Growth Hormone Isoform Responses to GABA Ingestion at Rest and after Exercise”; Medicine and Science in Sports and Exercise; January 2008. <http://www.ncbi.nlm.nih.gov/pubmed/18091016>

Shimada, Morio; Takashi Hasegawa; et al. “Anti-Hypertensive Effect of Gamma-Aminobutyric Acid (GABA)-Rich Chlorella on High-Normal Blood Pressure and Borderline Hypertension in Placebo-Controlled Double Blind Study”; Clinical and Experimental Hypertension; June 2009. <http://www.ncbi.nlm.nih.gov/pubmed/19811362>

Vaz, Gisele Cristiane; Ana Paula Oliveira Bahia; et al. “Cardiovascular and Behavioral Effects Produced by Administration of Liposome-Entrapped GABA Into the Rat Central Nervous System”; Neuroscience; January 29, 2015. <http://www.ncbi.nlm.nih.gov/pubmed/25446344>

Yoshimura, Mineka; Tohru Toyoshi; et al. “Antihypertensive Effect of a γ-Aminobutyric Acid Rich Tomato Cultivar ‘DG03-9’ in Spontaneously Hypertensive Rats”; Journal of Agricultural and Food Chemistry; January 13, 2010. <http://www.ncbi.nlm.nih.gov/pubmed/20050705>




L-Lysine Benefits, Uses, Side Effects and Functions

Discover the Function, Sources and Benefits of the Health Supplement Ingredient L-Lysine, or 2,6-Diaminohexanoic Acid

Lysine – also known as L-lysine, Lys or (S)-2,6-diaminohexanoic acid – is an essential amino acid. This means that while lysine is important for maintaining good health, it is not manufactured by the body; therefore, it must be consumed through dietary sources or supplements. L-lysine can be found in high-protein foods and in select health and bodybuilding supplements, including HGH 30,000 Nanograms pills, HGF MAX, and CytoSport and Multi-Pro whey protein mixes.

Functions of L-Lysine

As an essential amino acid, L-lysine serves as a building block of protein and promotes proper growth. It plays an important role in producing carnitine and forming collagen within the body. Carnitine aids in converting fatty acids into energy and helps to lower cholesterol, while collagen supports bone health and tissue repair, particularly in the case of tendons, cartilage and skin. L-lysine also appears to help the body absorb calcium, and it has antiviral effects. Some evidence suggests it may stimulate human growth hormone (HGH) production, thereby serving as a natural HGH releaser.

Sources of L-Lysine

Dietary sources of L-lysine include protein-rich foods such as red meat, pork, poultry, certain types of fish (such as cod and sardines), eggs and cheese. Plant-based sources include tofu and other forms of soy, nuts and legumes (including beans, peas and lentils). L-lysine may also be consumed in natural dietary supplements.

L-Lysine Benefits and Uses

Some evidence suggests L-lysine acts as a natural HGH releaser, or HGH secretagogue. Because of this potential to stimulate HGH production, L-lysine supplements are often taken to improve athletic performance and enhance muscle growth. Furthermore, lysine’s role in bone health and collagen formation means that it can help athletes recovering from injury by supporting bone and tissue repair.

One of the most common uses of L-lysine leverages its antiviral properties to prevent outbreaks of cold sores and genital herpes resulting from the herpes simplex virus (HSV). It appears to work by blocking the activity of arginine, which stimulates HSV replication. Because L-lysine helps the body absorb calcium and promotes collagen production, researchers believe it may also help prevent bone loss due to osteoporosis.

Side Effects of L-Lysine and Potential Interactions

L-lysine supplements are generally considered safe for adults; no side effects have been reported by healthy users at standard dosages. However, excessive doses may contribute to gallstones or renal dysfunction. Individuals with kidney or liver disease are advised to confer with a doctor before taking L-lysine supplements. In addition, anyone using aminoglycoside antibiotics (such as gentamicin, neomycin or streptomycin) should be aware of possible interaction with L-lysine, which may increase the risk of nephrotoxicity.

More detailed safety information on L-lysine dosages, side effects and interactions can be found on the University of Maryland Medical Center website. As with any medication or health supplement, it is best to consult your physician before taking dietary supplements containing L-lysine.

L-Lysine Research and Studies

Numerous studies have examined the use of L-lysine to treat medical conditions such as the herpes simplex virus (HSV), osteoporosis and cardiovascular disease. Researchers have reported that L-lysine appears to reduce the occurrence, severity and healing time of HSV infections and to minimize the associated symptoms, including cold sores and mouth ulcers. Animal studies have indicated that L-lysine may be effective in preventing and treating osteoporosis and cardiovascular disease; however, further human studies are needed.

Several studies suggest that L-lysine has the ability to enhance secretion of human growth hormone (HGH), thereby contributing to improved muscle mass and strength. Researchers emphasized that HGH production varied according to such factors as the training status, sex, age and diet of the individual. Many athletes and bodybuilders contend that L-lysine improves performance and strength; and while definitive human studies have yet to be published, animal studies have repeatedly shown that L-lysine produced greater muscularity in swine and other monogastric animals. Other research has examined the effects of L-lysine on wounds, bone fractures and muscle injuries. The findings suggest that lysine plays a positive role in bone and tissue repair; therefore, it may have the potential to help athletes recover from injuries and intense workouts.

For additional L-lysine research, refer to the PubMed site sponsored by the National Institutes of Health (NIH).

HGH.com Supplements With L-Lysine

Athletes, bodybuilders and fitness enthusiasts who wish to reap the benefits of L-lysine can find this essential amino acid in these natural health and bodybuilding supplements from HGH.com:

HGF MAX – Purity Select HGF MAX capsules are formulated to boost HGH production with a proprietary blend of ingredients, including L-lysine and other amino acids. This powerful dietary supplement can help build muscle, improve muscle tone, increase stamina and accelerate metabolism.

HGH 30,000 Nanograms – Purity Select’s popular HGH pills are designed to enhance growth hormone production through a combination of L-group amino acids, including L-lysine. HGH 30,000 Nanograms capsules help support muscle growth, burn fat, boost energy, and provide other health benefits.

CytoSport Vanilla Whey Protein – One serving of low-lactose, low-fat, CytoSport whey protein contains 10 grams of L-lysine and 18 grams of protein. This vanilla-flavored drink mix is intended to help athletes develop lean muscle mass and hasten recovery from intense training.

Multi-Pro Chocolate Whey Protein – With 1.9 grams of L-lysine and 24 grams of protein per serving, this complete protein supplement is formulated to build muscle, decrease body fat and improve immune system health.

Champion Nutrition Amino Shooter + Creatine – This pre-workout drink mix features nine amino acids, including 1,100 milligrams of L-lysine, yet contains no fat, carbs or cholesterol. It is designed to preserve hard-earned muscle while providing added energy for a more effective workout.

References (Function, Sources, Benefits/Uses and Side Effects/Interactions):

Bond, Owen. “What Does Lysine Do for Your Body?”; published in the “Food and Health” section on Livestrong.com; February 2, 2014. <http://www.livestrong.com/article/362472-what-does-lysine-do-for-your-body>

National Center for Biotechnology Information, U.S. National Library of Medicine. “L-lysine”; Compound Summary for CID 5962 in PubChem Open Chemistry Database; accessed April 27, 2015. <http://pubchem.ncbi.nlm.nih.gov/compound/L-lysine>

University of Maryland Shore Regional Health. “Amino Acids”; published in the “Medical Reference Guide” section; last updated April 23, 2014. <http://umm.edu/system-hospital-sites/shore-health/health/medical/ency/articles/amino-acids>

University of Maryland Shore Regional Health. “Lysine”; published in the “Medical Reference Guide” section; last updated May 7, 2013. <http://umm.edu/health/medical/altmed/supplement/lysine>

WebMD and Natural Medicines Comprehensive Database. “Lysine”; published under “Vitamins & Supplements”; accessed April 27, 2015. <http://www.webmd.com/vitamins-supplements/ingredientmono-237-lysine.aspx?activeingredientid=237&activeingredientname=lysine>

Research Sources:

Chromiak, Joseph A. and Jose Antonio. “Use of Amino Acids as Growth Hormone-Releasing Agents by Athletes.”; Nutrition; July/August 2001. <http://www.ncbi.nlm.nih.gov/pubmed/12093449>

Dort, Junio; Nadine LeBlanc; et al. “Beneficial Effects of Cod Protein on Inflammatory Cell Accumulation in Rat Skeletal Muscle after Injury Are Driven by Its High Levels of Arginine, Glycine, Taurine and Lysine”; PLoS One; October 4, 2013. <http://www.ncbi.nlm.nih.gov/pubmed/24124612>

Fini, Milena; Roberto Giardino; et al. “Role of Lactose, Arginine and Lysine Combination in Fracture Healing: An Experimental Study”; Annali Italiani di Chirurgia; January/February 1996. <http://www.ncbi.nlm.nih.gov/pubmed/8712622>

Fini, Melena; Paola Torricelli; et al. “Effect of L-Lysine and L-Arginine on Primary Osteoblast Cultures From Normal and Osteopenic Rats”; Biomedicine & Pharmacotherapy; May 2001. <http://www.ncbi.nlm.nih.gov/pubmed/11393808>

Flodin, Nestor W. “The Metabolic Roles, Pharmacology, and Toxicology of Lysine”; Journal of the American College of Nutrition; February 1997. <http://www.ncbi.nlm.nih.gov/pubmed/9013429>

Fürst, Peter. “Dietary L-Lysine Supplementation: A Promising Nutritional Tool in the Prophylaxis and Treatment of Osteoporosis”; Nutrition; January/February 1993 .<http://www.ncbi.nlm.nih.gov/pubmed/8467115>

Griffith, Richard S.; David E. Walsh; et al. “Success of L-Lysine Therapy in Frequently Recurrent Herpes Simplex Infection: Treatment and Prophylaxis”; Dermatologica; 1987. <http://www.ncbi.nlm.nih.gov/pubmed/3115841>

Liao, Shengfa F.; Taiji Wang; and Naresh Regmi. “Lysine Nutrition in Swine and the Related Monogastric Animals: Muscle Protein Biosynthesis and Beyond”; SpringerPlus; March 27, 2015. <http://www.ncbi.nlm.nih.gov/pubmed/25830085>

Morales-Trejo, Adriana; Héctor García-Villalobos; et al. “Effect of L-Lysine on Expression of Selected Genes, Serum Concentration of Amino Acids, Muscle Growth and Performance of Growing Pigs”; Journal of Animal Physiology and Animal Nutrition; October 29, 2014. <http://www.ncbi.nlm.nih.gov/pubmed/25354230>

Ozden, Feyza Otan; Ahmet Yasar Turanli; et al. “Clinical Success of Lysine in Association With Serumal and Salivary Presence of HSV-1 in Patients With Recurrent Aphthous Ulceration”; Journal of Experimental and Integrative Medicine; January 2011 <http://www.scopemed.org/?mno=6571>

Shimomura, Akihiro; Isao Matsui; et al. “Dietary l-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats”; Journal of the American Society of Nephrology; March 20, 2014. <http://jasn.asnjournals.org/content/early/2014/03/19/ASN.2013090967.full>

Spallotta, Francesco; Chiara Cencioni; et al. “Enhancement of Lysine Acetylation Accelerates Wound Repair”; Communicative & Integrative Biology; September 2013. <http://www.ncbi.nlm.nih.gov/pubmed/24265859>

Suminski, Richard R.; Robert J. Robertson; et al. “Acute Effect of Amino Acid Ingestion and Resistance Exercise on Plasma Growth Hormone Concentration in Young Men”; International Journal of Sport Nutrition; March 1997. <http://www.ncbi.nlm.nih.gov/pubmed/9063764>

Tomblin, Jr., Frankie A. and Kristy H. Lucas. “Lysine for Management of Herpes Labialis”; American Journal of Health-System Pharmacy; February 15, 2001. <http://www.ncbi.nlm.nih.gov/pubmed/11225166>




February 2015 Tips from IFBB Pros Presented by HGH.com

HGH.com Presents IFBB Pros & Tips: February 2015 Edition

Who better to get bodybuilding tips and tricks from than the IFBB Pros? For this month’s edition of HGH.com’s Tips from IFBB Pros, we’ve gathered a few video clips and added more to the corresponding Pinterest board. We begin with training exercises from Alice Matos, move onto an amazing back and chest workout with Brandon Curry, then round it out with the top three winners of the 2015 IFBB Pro Western Cup.

Training with IFBB Bikini Pro Alice Matos

Get an inside look at some of the exercises IFBB Bikini Pro Alice Matos does. This Brazilian bombshell demonstrates some unique training methods and even has her workout partners help her out.

We found some other interesting tidbits from an interview Alice did for SimplyShredded.com. When asked if she could only pick three exercises what would the would be and why, she chose

  • Barbell Squats
  • Bench Press
  • Back Row

Her reasoning is that they're all compound movements, so they use multiple major muscle groups simultaneously. She finds these types of exercises are ideal when building muscle mass.

Brandon Curry Gets Ready for the 2015 Arnold Classic

With only three-and-a-half weeks left until the Arnold Classic, IFBB Pro Brandon Curry hits the Bev Francis Powerhouse Gym. He's been training his heart out while focusing on quality mass gains and improvements. In this video, we take a look at his back and chest workout as he trains both areas at the same time. His workout includes:

  • Pull Ups
  • Low Row Machine
  • Close Grip Pull Downs
  • Kroc Row
  • Dumbbell Pullover
  • Decline
  • Dips
  • Pec Deck Machine
  • Incline Dumbbell Flyes

The Best of the 2015 IFBB Pro Western Cup

In Jon Lindsay's Muscle Contest, the 2015 IFBB Pro Western Cup, these three buff gentlemen placed for the men's physique competition:

  • Frank Ortega
  • Joseph Lee
  • Patrick Fulgham

After the show, they were interviewed by Tamer El Guindy, VP of Operations for Muscle Contest. When asked how long it took him to prepare for this competition, Patrick Fulgham says he did a 12-week prep. What's next for Joseph Lee? He will be back for the Muscle Grand Prix in April and is working toward going to the men's physique Olympia competition.

Last, but not least, we hear from, first place winner, Frank Ortega who had to make some sacrifices during the holiday and completed a 15 to 16-week prep for this competition. After recently suffering an injury, he just focused on making his pro debut and wants 2015 to be the year he brings his best.

Get Even More Pumped with IFBB Pros & Tips on Pinterest

Make sure to check out our dedicated IFBB Pros & Tips Pinterest board for even more motivation and helpful tidbits from the IFBB Pros. Whether you're looking for inspiration, workout tips or nutrition-related pins, this Pinterest board has it all from IFBB pros. Follow us on Pinterest for all sorts of bodybuilding boards. We'll continue to update this board and we frequently create new bodybuilding-related boards as well:

Follow Bodybuilding's IFBB Pros & Tips Pinterest board.

 




Do HGH Releasers Really Work for Bodybuilders and Athletes?

A Candid Conversation About HGH Releasers and Other Natural Bodybuilding Supplements

By Dan Smith of HGH.com

Growth hormones have always been a hot – and often controversial – topic in the bodybuilding and sports worlds. As the public voice of HGH.com and Purity Select, I’ve frequently addressed the benefits of HGH releasers and bodybuilding supplements through our blog posts, HGH community, social media platforms, sponsored events and news releases. But there’s nothing quite as inspiring as discussing the subject face-to-face with fellow bodybuilders and fitness enthusiasts, as I was reminded during a recent visit to my local gym.

A few days ago, while I was in the middle of my leg workout routine, a guy at the weight machine next to me struck up a conversation. He told me that he used to lift in high school, and was slowly getting back into it again after a lengthy hiatus – and was finding it much more challenging than he remembered. When he noticed my HGH.com shirt, he asked, “Do you use HGH? Does it really work?”

I told him that I’ve been using natural HGH supplements for years; and in a nod to an old TV commercial, I said, “Not only do I run HGH.com, I’m also a client.” He got the reference, and we both laughed. Then I asked him, “You know that HGH and testosterone levels naturally decrease over time, right?” He replied, “Sure, that’s common knowledge. But…isn’t HGH illegal without a prescription?”

This is a question I’ve often been asked by those who are new to HGH; it seems that despite the steadily growing popularity of HGH supplements, many myths and misconceptions still remain. So I went on to explain the differences between prescription-only synthetic HGH injections and over-the-counter natural health supplements that contain HGH releasers. As I saw the awareness and interest dawn in my fellow weightlifter’s eyes, it occurred to me that many others have the same questions – and that I could play a role in educating the public on this topic.

In light of that goal, HGH.com recently issued a news release to the national media spotlighting how legal, non-synthetic growth hormone supplements provide an over-the-counter alternative to HGH injections. And I decided to write this blog post to address the questions I was asked by my new gym friend and by numerous bodybuilders, athletes and fitness enthusiasts before him. Without further ado, here are my answers to the most commonly asked questions about HGH releasers and HGH.com health and bodybuilding supplements:

Why is HGH so popular among bodybuilders and athletes?

Human growth hormone – better known as HGH – is a polypeptide hormone secreted by the pituitary gland. It is essential for growth and development, which is why the highest naturally occurring HGH levels are found in children and teens; and it is also involved in regulating body composition, metabolizing sugar and fat, and building skeletal muscle. After adolescence, HGH levels gradually decrease over time – and that’s where HGH supplementation comes in. Because HGH plays a role in growing and repairing muscle, many athletes, bodybuilders and fitness enthusiasts rely on HGH supplements to help them build muscle and recover from intense training.

How are HGH releasers different from HGH injections?

HGH injections generally involve a synthetic form of growth hormones; each dose introduces HGH directly to the bloodstream through subcutaneous or intramuscular injection. By contrast, most HGH releasers – also known as HGH secretagogues – primarily feature natural ingredients that are consumed orally in capsule, liquid or powder form. Rather than elevating HGH levels with externally manufactured growth hormones, the HGH releasers in natural dietary supplements are intended to stimulate the body to produce more of its own HGH.

Why use natural HGH releasers versus synthetic HGH injections?

I personally prefer natural HGH supplements because I believe they are safer and easier to use than injections, as well as more affordable; and I know a lot of athletes and bodybuilders who feel the same way. Synthetic HGH can be very expensive, and it requires a prescription from a supervising physician. It has also been associated with a number of reported side effects, including joint pain, muscle pain, carpal tunnel syndrome, edema, and numbness and tingling of the skin. And let’s face it – a lot of people simply hate needles, and would rather take supplements orally.

But perhaps the biggest argument in favor of over-the-counter natural HGH supplementation is that the FDA has only approved the use of injectable synthetic HGH for the treatment of specific diseases and medical conditions. Using HGH injections for “off-label” purposes – such as bodybuilding, weight-loss and anti-aging benefits – is considered “illicit”, and is therefore illegal if the synthetic growth hormone was not prescribed by a supervising physician. (The U.S. Drug Enforcement Administration has published a helpful HGH fact sheetwith more details on the use and abuse of synthetic HGH.)

Since the majority of herbal dietary supplements are not FDA-regulated, consumers can legally purchase and use non-synthetic HGH releasers for muscle building, weight loss and recovery from intense workouts. And because HGH.com sells natural HGH and bodybuilding supplements rather than injectables, our over-the-counter products can be legally purchased and shipped anywhere in the United States – and in most other countries around the world.

Which HGH releasers are the best for bodybuilders?

HGH.com sells a variety of natural HGH releasers, including many “stackable” bodybuilding supplements that are designed to work together to produce visible results. But if I were asked to suggest just one product for someone who is getting started with HGH supplements, I would recommend our Purity Select HGF MAX supplements. These capsules contain a potent combination of natural ingredients that are formulated to naturally stimulate HGH production. Our proprietary HGF MAX blend includes L-arginine, L-glutamine, L-lysine, L-tyrosine, L-ornithine, glycine, gamma-aminobutyric acid (GABA), phosphatidyl choline, astragalus extract and deer antler velvet. Not only is HGF MAX designed to build lean muscle and aid in muscle recovery, but it has the potential to deliver a host of other benefits: enhanced metabolism and fat-burning capabilities; immune system support; increased stamina; anti-aging effects; more restful sleep; and improved skin, hair and nails. Other popular Purity Select HGH releasers include Somatropinne HGH, DBol-GH, Ana-GH, HGH Testosterone Plus, HGH 30,000 Nanograms Pills and 30,000 HGH Nanograms Spray.

Which HGH releasers are the best for recovery?

Most of the products we feature on HGH.com help support muscle recovery following intense training. If I were to narrow it down to my top three choices for hardcore bodybuilders, I would suggest Purity Select Somatropinne HGH, HGF MAX, and/or Cut and Ripped Plus. However, if anyone has questions about specific supplements or ingredients, we’re happy to provide answers. We have customer services representatives available via phone (888-399-5993), email (support@hgh.com) and live chat. Or you can connect with us on Facebook, Twitter and other online channels.

Any other advice?

Sure; there are a few parting points I would like to share:

  • First, always follow the usage and dosing instructions listed on the HGH supplement packaging. Our Good Manufacturing Practice (GMP) labs carefully formulate the proper dosages of each supplement and explain how and when to take them for optimal benefits.
  • Second, be aware that heat can decrease the potency of certain supplement ingredients. So, be sure to store your HGH releasers in a cool, dry place. And whether you’re using capsules or powdered drink mixes, always take your supplements with cold (or room-temperature) liquids – save the hot beverages for well before or after your supplements.
  • Third, don’t hesitate to reach out to others for help and recommendations. We’re always here to answer your questions, and you’ll likely find that fellow weightlifters at your local gym are happy to share workout and supplement suggestions. Also, you can connect with bodybuilders you admire online. Our HGH.com-sponsored athletes – award-winning IFBB pros Richard “Tricky” Jackson, Ben White and Tara Silzer – regularly provide guidance and advice to their fans and followers. And finally, visit our HGH.com blog frequently; we often publish workout videos, articles and links to helpful resources.


Have another question for us? Want to join in the debate regarding synthetic HGH injections versus natural HGH releasers? Join the conversation via our HGH.com Facebook page and HGH.com Twitter profile!




Do HGH Releasers Really Work for Bodybuilders and Athletes?

A Candid Conversation About HGH Releasers and Other Natural Bodybuilding Supplements

By Dan Smith of HGH.com

HGH Releaser Benefits - Healthy You!!

Growth hormones have always been a hot – and often controversial – topic in the bodybuilding and sports worlds. As the public voice of HGH.com and Purity Select, I’ve frequently addressed the benefits of HGH releasers and bodybuilding supplements through our blog posts, HGH community, social media platforms, sponsored events and news releases. But there’s nothing quite as inspiring as discussing the subject face-to-face with fellow bodybuilders and fitness enthusiasts, as I was reminded during a recent visit to my local gym.

A few days ago, while I was in the middle of my leg workout routine, a guy at the weight machine next to me struck up a conversation. He told me that he used to lift in high school, and was slowly getting back into it again after a lengthy hiatus – and was finding it much more challenging than he remembered. When he noticed my HGH.com shirt, he asked, “Do you use HGH? Does it really work?”

I told him that I’ve been using natural HGH supplements for years; and in a nod to an old TV commercial, I said, “Not only do I run HGH.com, I’m also a client.” He got the reference, and we both laughed. Then I asked him, “You know that HGH and testosterone levels naturally decrease over time, right?” He replied, “Sure, that’s common knowledge. But…isn’t HGH illegal without a prescription?”

This is a question I’ve often been asked by those who are new to HGH; it seems that despite the steadily growing popularity of HGH supplements, many myths and misconceptions still remain. So I went on to explain the differences between prescription-only synthetic HGH injections and over-the-counter natural health supplements that contain HGH releasers. As I saw the awareness and interest dawn in my fellow weightlifter’s eyes, it occurred to me that many others have the same questions – and that I could play a role in educating the public on this topic.

In light of that goal, HGH.com recently issued a news release to the national media spotlighting how legal, non-synthetic growth hormone supplements provide an over-the-counter alternative to HGH injections. And I decided to write this blog post to address the questions I was asked by my new gym friend and by numerous bodybuilders, athletes and fitness enthusiasts before him. Without further ado, here are my answers to the most commonly asked questions about HGH releasers and HGH.com health and bodybuilding supplements:

Why is HGH so popular among bodybuilders and athletes?

Human growth hormone – better known as HGH – is a polypeptide hormone secreted by the pituitary gland. It is essential for growth and development, which is why the highest naturally occurring HGH levels are found in children and teens; and it is also involved in regulating body composition, metabolizing sugar and fat, and building skeletal muscle. After adolescence, HGH levels gradually decrease over time – and that’s where HGH supplementation comes in. Because HGH plays a role in growing and repairing muscle, many athletes, bodybuilders and fitness enthusiasts rely on HGH supplements to help them build muscle and recover from intense training.

How are HGH releasers different from HGH injections?

HGH injections generally involve a synthetic form of growth hormones; each dose introduces HGH directly to the bloodstream through subcutaneous or intramuscular injection. By contrast, most HGH releasers – also known as HGH secretagogues – primarily feature natural ingredients that are consumed orally in capsule, liquid or powder form. Rather than elevating HGH levels with externally manufactured growth hormones, the HGH releasers in natural dietary supplements are intended to stimulate the body to produce more of its own HGH.

Why use natural HGH releasers versus synthetic HGH injections?

I personally prefer natural HGH supplements because I believe they are safer and easier to use than injections, as well as more affordable; and I know a lot of athletes and bodybuilders who feel the same way. Synthetic HGH can be very expensive, and it requires a prescription from a supervising physician. It has also been associated with a number of reported side effects, including joint pain, muscle pain, carpal tunnel syndrome, edema, and numbness and tingling of the skin. And let’s face it – a lot of people simply hate needles, and would rather take supplements orally.

But perhaps the biggest argument in favor of over-the-counter natural HGH supplementation is that the FDA has only approved the use of injectable synthetic HGH for the treatment of specific diseases and medical conditions. Using HGH injections for “off-label” purposes – such as bodybuilding, weight-loss and anti-aging benefits – is considered “illicit”, and is therefore illegal if the synthetic growth hormone was not prescribed by a supervising physician. (The U.S. Drug Enforcement Administration has published a helpful HGH fact sheet with more details on the use and abuse of synthetic HGH.)

Since the majority of herbal dietary supplements are not FDA-regulated, consumers can legally purchase and use non-synthetic HGH releasers for muscle building, weight loss and recovery from intense workouts. And because HGH.com sells natural HGH and bodybuilding supplements rather than injectables, our over-the-counter products can be legally purchased and shipped anywhere in the United States – and in most other countries around the world.

Which HGH releasers are the best for bodybuilders?

HGH.com sells a variety of natural HGH releasers, including many “stackable” bodybuilding supplements that are designed to work together to produce visible results. But if I were asked to suggest just one product for someone who is getting started with HGH supplements, I would recommend our Purity Select HGF MAX supplements. These capsules contain a potent combination of natural ingredients that are formulated to naturally stimulate HGH production. Our proprietary HGF MAX blend includes L-arginine, L-glutamine, L-lysine, L-tyrosine, L-ornithine, glycine, gamma-aminobutyric acid (GABA), phosphatidyl choline, astragalus extract and deer antler velvet. Not only is HGF MAX designed to build lean muscle and aid in muscle recovery, but it has the potential to deliver a host of other benefits: enhanced metabolism and fat-burning capabilities; immune system support; increased stamina; anti-aging effects; more restful sleep; and improved skin, hair and nails. Other popular Purity Select HGH releasers include Somatropinne HGH, DBol-GH, Ana-GH, HGH Testosterone Plus, HGH 30,000 Nanograms Pills and 30,000 HGH Nanograms Spray.

Which HGH releasers are the best for recovery?

Most of the products we feature on HGH.com help support muscle recovery following intense training. If I were to narrow it down to my top three choices for hardcore bodybuilders, I would suggest Purity Select Somatropinne HGH, HGF MAX, and/or Cut and Ripped Plus. However, if anyone has questions about specific supplements or ingredients, we’re happy to provide answers. We have customer services representatives available via phone (888-399-5993), email (support@hgh.com) and live chat. Or you can connect with us on Facebook, Twitter and other online channels.

Any other advice?

Sure; there are a few parting points I would like to share:

  • First, always follow the usage and dosing instructions listed on the HGH supplement packaging. Our Good Manufacturing Practice (GMP) labs carefully formulate the proper dosages of each supplement and explain how and when to take them for optimal benefits.
  • Second, be aware that heat can decrease the potency of certain supplement ingredients. So, be sure to store your HGH releasers in a cool, dry place. And whether you’re using capsules or powdered drink mixes, always take your supplements with cold (or room-temperature) liquids – save the hot beverages for well before or after your supplements.
  • Third, don’t hesitate to reach out to others for help and recommendations. We’re always here to answer your questions, and you’ll likely find that fellow weightlifters at your local gym are happy to share workout and supplement suggestions. Also, you can connect with bodybuilders you admire online. Our HGH.com-sponsored athletes – award-winning IFBB pros Richard “Tricky” Jackson, Ben White and Tara Silzer – regularly provide guidance and advice to their fans and followers. And finally, visit our HGH.com blog frequently; we often publish workout videos, articles and links to helpful resources.


Have another question for us? Want to join in the debate regarding synthetic HGH injections versus natural HGH releasers? Join the conversation via our HGH.com Facebook page and HGH.com Twitter profile!




L-Glutamine Benefits, Uses, Side Effects and Functions

Discover the Function, Sources and Benefits of the Health Supplement Ingredient L-Glutamine, or 2-Amino-4-Carbamoylbutanoic Acid

Glutamine – also known as L-glutamine and 2-amino-4-carbamoylbutanoic acid – is considered a conditionally essential amino acid. This means that while the body is usually able to produce sufficient amounts of glutamine for its daily needs, L-glutamine supplementation may be required in instances when glutamine is depleted due to stressors. Illness, injury, surgery, chemotherapy and intense exercise can all deplete glutamine levels. Individuals who need to replenish L-glutamine can obtain it through certain food sources as well as in natural health and bodybuilding supplements such as HGF-MAX, HGH 30,000 Nanograms pills and spray, and whey protein mixes.

Functions of L-Glutamine

Amino acids serve as the building blocks of protein, and glutamine acts as a precursor for protein synthesis. It is primarily produced by and stored within muscle, and distributed to other organs via the bloodstream. L-glutamine is believed to act as a human growth hormone (HGH) releaser, also known as an HGH secretagogue. In addition, glutamine is the major fuel source for enterocytes (intestinal absorptive cells) as well as lymphocytes and macrophages (white blood cells that play a key role within the immune system), and it appears to be required for healthy brain function and digestion. Furthermore, L-glutamine is involved in nitrogen exchange and plays a critical role in removing excess ammonia resulting from protein catabolism.

Sources of L-Glutamine

Dietary sources of glutamine include meat (beef, pork and poultry); dairy (milk, yogurt, ricotta cheese and cottage cheese); egg whites; leafy greens (raw spinach and cabbage); legumes (peanuts and soybeans); and grains (wheat, corn and barley). L-glutamine may also be consumed directly – in powder, tablet, capsule or liquid form – as part of a natural dietary supplement.

L-Glutamine Benefits and Uses

Considering L-glutamine’s role as an HGH releaser and precursor for protein synthesis, and given that glutamine levels typically drop following intense exercise, this amino acid has become a popular ingredient in health and bodybuilding supplements. Rigorous workouts and lifting reduce intramuscular glutamine stores and can weaken the muscles if levels are not replenished. That’s why athletes, bodybuilders and fitness enthusiasts often take L-glutamine supplements to aid in muscle maintenance, promote cell renewal and support the immune system – particularly when undergoing intensive training.

For many of the same reasons, L-glutamine can be a useful dietary supplement for individuals recovering from illness, injury, infections, severe burns and surgery. By strengthening the immune system, L-glutamine helps to fight off infections and neutralize excess ammonia and cortisol in the body. Its role in protecting the gastrointestinal lining may help individuals suffering from inflammatory bowel disease (IBD) or short-bowel syndrome. It can help HIV/AIDS patients avoid weight loss, as it enables the intestines to better absorb nutrients. Evidence also suggests L-glutamine may be beneficial for cancer patients undergoing chemotherapy by helping to combat cachexia (weight loss, muscle atrophy and fatigue) and stomatitis (inflammation and soreness in the mouth).

Side Effects of L-Glutamine and Potential Interactions

L-glutamine supplements are generally considered safe for adults, and no significant side effects have been reported in healthy users. However, L-glutamine may exacerbate symptoms in people with certain medical conditions, including liver disease, hepatic encephalopathy, kidney disease, Reye syndrome, seizures and mania.

Interactions are possible with some medications; for example, L-glutamine supplements may decrease the effectiveness of lactulose and anticonvulsants. There has also been conflicting evidence concerning the use of glutamine for cancer patients; while some studies confirm its beneficial effects, others indicate it may interact with cancer medications or potentially stimulate tumor growth. More detailed safety information on L-glutamine side effects and interactions can be found on WebMD. As with any medication or health supplement, it is best to consult your physician before taking dietary supplements containing L-glutamine.

L-Glutamine Research and Studies

Numerous research studies have explored the impact of L-glutamine supplements on subjects ranging from healthy athletes to critically ill patients. In terms of its efficacy as an HGH releaser, an article published in The American Journal of Clinical Nutrition indicated that a small oral L-glutamine load is capable of raising alkaline reserves and increasing HGH concentration in plasma. Another study cited in Nutritional Neuroscience found that an oral supplement containing L-glutamine, glycine and niacin was shown to enhance HGH secretion in healthy middle-aged and elderly subjects.

According to the Asian Journal of Sports Medicine, researchers found that L-glutamine and carbohydrate supplementation improved the physical performance of athletes during repeated competitions by preventing anaerobic power decrease. An article published in the Journal of the International Society of Sports Nutrition reported that L-alanyl-L-glutamine supplementation provided a significant ergogenic benefit by increasing time to exhaustion during endurance exercise. Animal studies also showed promising results; in Cell Biochemistry and Function, scientists examined muscle damage and inflammation in rats following prolonged exercise and found that L-glutamine supplementation diminished inflammation biomarkers and the inflammatory response.

Other research has explored L-glutamine’s effects from a medical perspective. A meta-analysis published in Current Opinion in Clinical Nutrition & Metabolic Care concluded that L-glutamine has a beneficial effect on infectious complications and reduces the length of hospital stays, and noted that it may reduce morbidity and mortality in critically ill patients. For additional L-glutamine research, refer to the PubMed site sponsored by the National Institutes of Health (NIH).

HGH.com Supplements With L-Glutamine

Athletes, bodybuilders and fitness enthusiasts can replenish glutamine levels and leverage the positive impact of L-glutamine with natural HGH and bodybuilding supplements from HGH.com:

HGF MAX – These capsules were scientifically developed to elevate HGH levels with key ingredients such as L-glutamine and other amino acids, which collectively help to build muscle, enhance muscle tone, increase metabolism and improve stamina.

HGH 30,000 Nanograms Pills and HGH 30,000 Nanograms Spray – Available in capsule and spray forms, HGH 30,000 Nanograms stimulates HGH production through a powerful combination of L-group amino acids, including L-glutamine. These oral supplements support muscle growth, fat-burning, increased energy and other benefits.

Multi-Pro Chocolate Whey Protein – With more than 3.7 grams of L-glutamine and 24 grams of protein per serving, Multi-Pro is a complete protein supplement that is designed to help users gain muscle, lose body fat and support the immune system.

Elite Whey Protein Butter Toffee and Elite Whey Protein Chocolate Mint – Each serving of Elite whey protein delivers more than 3.5 grams of glutamine and glutamine precursors plus 5 grams of branched-chain amino acids to help grow and strengthen muscle while aiding in muscle repair and recovery.

CytoSport Vanilla Whey Protein – One serving of low-fat, low-lactose, CytoSport whey protein contains 18 grams of protein and is naturally rich in L-glutamine and branched-chain amino acids. It aids users in developing lean muscle mass and recovering more quickly after intense training.

CytoSport EvoPro Berry – Each scoop of EvoPro Berry contains 3 grams of L-glutamine and 26 grams of protein, yet has very little carbohydrates or fat. It helps to promote lean muscle mass, stimulate growth receptors and sustain an anabolic state.

Mega Shake Strawberry – Featuring a powerful blend of active ingredients – including L-glutamine – Mega Shake provides 32 grams of total protein per serving. It is formulated to help increase muscle tone, reduce body fat, provide energy and support muscle recovery.

NOX-CG3 Fruit Punch and NOX-CG3 Blue Raspberry – With a blend of L-arginine, creatine and L-glutamine, this advanced formulation is designed to boost energy, enhance nutrient absorption and reduce recovery time after strenuous workouts.

NxLabs Plasmavol, NxLabs Pump System and NxLabs Ultimate Muscle Expansion Pack – These NxLabs supplements contain L-glutamine and other amino acids to help accelerate nitric oxide production, enhance muscle pumps and vascularity, and increase strength.


References (Function, Sources, Benefits/Uses and Side Effects/Interactions):

Memorial Sloan Kettering Cancer Center. “Glutamine”; published under “About Herbs, Botanicals & Other Products” within Integrative Medicine area of website; last updated February 21, 2013. <http://www.mskcc.org/cancer-care/herb/glutamine>

University of Maryland Medical Center. “Glutamine”; published under the “Complementary and Alternative Medicine Guide” on the website; last updated May 7, 2013. <http://umm.edu/health/medical/altmed/supplement/glutamine>

Presser, Art. “Amino Acids”; Smart Supplementation, published by Huntington College of Health Sciences; 2009. <http://www.hchs.edu/literature/Amino%20Acids.pdf>

WebMD and Natural Medicines Comprehensive Database. “Glutamine”; published under “Vitamins & Supplements”; accessed August 14, 2014. <http://www.webmd.com/vitamins-supplements/ingredientmono-878-glutamine.aspx?activeingredientid=878&activeingredientname=glutamine>

Research Sources:

Arwert, Lucia I.; Deijen, Jan Berend; and Drent, Madeleine L. “Effects of An Oral Mixture Containing Glycine, Glutamine and Niacin on Memory, GH and IGF-I Secretion in Middle-aged and Elderly Subjects”; Nutritional Neuroscience; October 1, 2003. <http://www.ncbi.nlm.nih.gov/pubmed/14609312>

Cruzat, Vinicius Fernandes; Rogero, Marcelo Macedo; and Tirapegu, Julio. “Effects of Supplementation With Free Glutamine and the Dipeptide Alanyl-Glutamine on Parameters of Muscle Damage and Inflammation in Rats Submitted to Prolonged Exercise”; Cell Biochemistry and Function; January 2010. <http://www.ncbi.nlm.nih.gov/pubmed/19885855>

Hoffman, Jay R.; Ratamess, Nicholas A.; et al. “Examination of the Efficacy of Acute L-Alanyl-L-Glutamine Ingestion During Hydration Stress in Endurance Exercise”; Journal of the International Society of Sports Nutrition; February 3, 2010. <http://www.ncbi.nlm.nih.gov/pubmed/20181080>

Khorshidi-Hosseini, Mahdi and Nakhostin-Roohi, Babak. “Effect of Glutamine and Maltodextrin Acute Supplementation on Anaerobic Power”; Asian Journal of Sports Medicine; June 2013. <http://www.ncbi.nlm.nih.gov/pubmed/23802055>

Melis, Gerdien C.; ter Wengel, Nathalie; et al. “Glutamine: Recent Developments in Research on the Clinical Significance of Glutamine”; Current Opinion in Clinical Nutrition & Metabolic Care; January 2004. <http://www.ncbi.nlm.nih.gov/pubmed/15090905>

Welbourne, Thomas C. “Increased Plasma Bicarbonate and Growth Hormone After an Oral Glutamine Load”; The American Journal of Clinical Nutrition; May 1995. <http://www.ncbi.nlm.nih.gov/pubmed/7733028>




The Ingredients in the top HGH Supplement "HGF MAX" - Helping you with Muscle Growth

We at HGH.com are excited to introduce another amazing HGH supplement called HGF MAX (HGF:Human Growth Factor).
 
Like ANA-GH, the benefits to this breakthrough HGH Pill are profound. There is truly nothing else like it on the market.
 
Here's a list and explanation of the ingredients and how it's going to help you raise your HGH Levels, build muscles, act as an anti-aging supplement, increase your strength and stamina, and more. HGF MAX is the most potent and best HGH Supplement on the market, period.
  1. L-Arginine: Triple Growth Hormone LevelsStudies show that Arginine can as much as triple your growth hormone levels, even in old age, and mixed with the ingredients within HGF MAX, it can as much as multiply them by TEN! It can also help improve your exercise performance for high-intensity, short duration work outs. It’s also been linked to helping Erectile Dysfunction due to its ability to increase blood flow. Further - It increases fat burning, builds muscle tissue, boosts immunity, promotes healing, enhances male fertility, and more!
  2. L-Glutamine
    L-Glutamine is essential to your body and is used by your body during times of stress. It's important to your body's muscle maintenance. It increases energy levels and is known to add mental focus and alertness. It's also helpful with cell growth. Other studies have shown it to boost your immunity, lower cholesterol levels and lower blood pressure.

  3. L-Lysine
    Lysine is an essential amino acid that the human body cannot produce naturally. Lysine works with the other essential amino acids in HGF MAX to maintain growth, lean body mass, and the body's store of nitrogen. Lysine with the other ingredients in HGF MAX can multiply your growth hormone levels by as much as 10 times! It can also help with your sexual stamina.
  4. L-Tyrosine
    Tyrosine is used by the thyroid gland for the production of Thyroxine, another vital hormone shown in clinical studies to help reduce fatigue and depression, as well as regulate growth and metabolism.
  5. Glycine
    Glycine is one of the key stimulatory agents that encourages your pituitary gland to secrete HGH! It also has a calming effect on the brain and may play a role in the health of the prostate. Studies show that a clear and significant increase of serum HGH was observed after people were given Glycine.
  6. Astragalus extract
    Astragalus is used to boost the body's immune system as well as treating health conditions such as heart disease. Its antioxidant effects inhibit free radical production, thus helping to repair damaged cells and help stave off some of the signs and symptoms associated with aging.
  7. Deer Antler Velvet 
    Deer Antler Velvet is a powerful and natural source of natural source of glucosamine, chondroitin and collagen that can help you boost your strength and performance. In the 1980s, scientists tested the effects of deer antler velvet on the performance of top athletes, and the results were astonishing. Deer antler velvet helped increase the strength and muscle mass of athletes, and speed their recovery time from exercise, enabling them to shatter records. Deer Antler Velvet is a must in Performance Enhancers.
  8. GABA (Gamma-Aminobutyric acid) 
    GABA (Gamma-aminobutyric acid) is essential for brain metabolism, and is made in the body from another amino acid, glutamic acid. As human growth hormone is produced in the brain by the pituitary, GABA HgH releaser influences the brain environment in a positive way to facilitate the production and release of growth hormone.
  9. Phosphatidyl Choline
    This acts as an excellent emulsifier, facilitating the absorption of the other nutrients included in our HGF MAX. Phosphatidyl Choline also breaks down fat deposits in the body, making it helpful in the prevention of gallstones, atherosclerosis, heart disease, and liver problems, depression, memory loss, and neurological disorders.
  10. L-Ornithine (L-Ornithine HCl)
    L-Ornithine is the most potent amino acid ever studied for stimulating the production and release ofHuman Growth Hormone from the pituitary gland. Studies of L-Ornithine have shown the ability to regenerate the thymus gland, liver, and heart tissue, enhance muscle growth, and increase immune system function.
In closing, you cannot miss out on HGF MAX. This is going to be another game changer by HGH.com and Purity Select!






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